:root {
  --brand: #8B5CF6;
  --brand-hover: #7C3AED;
  --accent: #06B6D4;
  --text: #111827;
  --text-secondary: #6B7280;
  --bg: transparent;
  --surface: #FFFFFF;
  --border: #E5E7EB;
  --path: #EF4444;
  --lp: #F97316;
  --vus: #EAB308;
  --lb: #22C55E;
  --ben: #3B82F6;
  --font: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', sans-serif;
}

*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }

body {
  font-family: var(--font);
  background: var(--bg);
  color: var(--text);
  -webkit-font-smoothing: antialiased;
}

#app {
  max-width: 420px;
  margin: 0 auto;
}

.widget {
  background: var(--surface);
  border-radius: 16px;
  box-shadow: 0 1px 3px rgba(0,0,0,0.06), 0 4px 16px rgba(0,0,0,0.04);
  border: 1px solid var(--border);
  overflow: hidden;
  max-width: 420px;
  height: 700px;
  display: flex;
  flex-direction: column;
}

/* Header bar */
.widget-content { flex: 1; overflow-y: auto; min-height: 0; scrollbar-width: thin; scrollbar-color: var(--border) transparent; }
.widget-content::-webkit-scrollbar { width: 4px; }
.widget-content::-webkit-scrollbar-track { background: transparent; }
.widget-content::-webkit-scrollbar-thumb { background: var(--border); border-radius: 2px; }
.widget-header { border-bottom: 1px solid var(--border); flex-shrink: 0; }
.widget-banner { position: relative; height: 60px; overflow: hidden; border-radius: 16px 16px 0 0; }
.banner-img { width: 100%; height: 100%; object-fit: cover; }
.banner-overlay { position: absolute; inset: 0; background: linear-gradient(135deg, rgba(139,92,246,0.7), rgba(6,182,212,0.5)); display: flex; flex-direction: column; justify-content: center; align-items: center; }
.banner-title { font-size: 22px; font-weight: 800; color: #fff; letter-spacing: -0.5px; text-shadow: 0 1px 3px rgba(0,0,0,0.2); font-family: var(--font); }
.banner-subtitle { font-size: 10px; color: rgba(255,255,255,0.85); font-weight: 500; }
.header-bottom { display: flex; align-items: center; justify-content: space-between; padding: 6px 16px; }

.widget-logo { display: flex; align-items: center; gap: 8px; font-weight: 500; font-size: 10px; color: var(--text-secondary); }
.widget-logo svg { flex-shrink: 0; }

.header-actions {
  display: flex;
  align-items: center;
  gap: 4px;
}

.icon-btn {
  background: none;
  border: none;
  cursor: pointer;
  padding: 6px;
  border-radius: 8px;
  color: var(--text-secondary);
  display: flex;
  align-items: center;
  transition: background 0.15s, color 0.15s;
}

.icon-btn:hover { background: var(--bg); color: var(--text); }

/* Search */
.search-wrap {
  position: relative;
  padding: 8px 16px;
}

.search-input {
  width: 100%;
  padding: 8px 12px 8px 32px;
  border: 1px solid var(--border);
  border-radius: 10px;
  font-size: 12px;
  font-family: var(--font);
  background: var(--bg);
  color: var(--text);
  outline: none;
  transition: border-color 0.15s;
}

.search-input:focus { border-color: var(--brand); }

.search-icon {
  position: absolute;
  left: 26px;
  top: 50%;
  transform: translateY(-50%);
  color: var(--text-secondary);
  pointer-events: none;
}

.search-dropdown {
  position: absolute;
  top: 100%;
  left: 16px;
  right: 16px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 10px;
  box-shadow: 0 8px 24px rgba(0,0,0,0.1);
  z-index: 100;
  max-height: 200px;
  overflow-y: auto;
  display: none;
}

.search-dropdown.open { display: block; }

.search-item {
  padding: 8px 12px;
  cursor: pointer;
  font-size: 12px;
  display: flex;
  justify-content: space-between;
  align-items: center;
  transition: background 0.1s;
}

.search-item:hover { background: var(--bg); }

.search-item .gene-sym { font-weight: 600; color: var(--text); }
.search-item .gene-count { color: var(--text-secondary); font-size: 11px; }

/* Big stat */
.big-stat {
  text-align: center;
  padding: 20px 16px 8px;
}

.big-number {
  font-size: 42px;
  font-weight: 800;
  color: var(--text);
  line-height: 1;
  letter-spacing: -1px;
}

.big-subtitle {
  font-size: 12px;
  color: var(--text-secondary);
  margin-top: 4px;
  line-height: 1.4;
}

.big-subtitle strong { color: var(--brand); font-weight: 600; }

/* Time range buttons */
.time-range {
  display: flex;
  gap: 4px;
  padding: 8px 16px;
  justify-content: center;
}

.time-btn {
  padding: 4px 10px;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface);
  font-size: 11px;
  font-family: var(--font);
  font-weight: 500;
  color: var(--text-secondary);
  cursor: pointer;
  transition: all 0.15s;
}

.time-btn:hover { border-color: var(--brand); color: var(--brand); }
.time-btn.active { background: var(--brand); color: #fff; border-color: var(--brand); }

/* Gene list */
.gene-list {
  padding: 4px 16px 12px;
}

.gene-list-title {
  font-size: 11px;
  font-weight: 600;
  color: var(--text-secondary);
  text-transform: uppercase;
  letter-spacing: 0.5px;
  margin-bottom: 6px;
}

.gene-row {
  display: flex;
  align-items: center;
  padding: 6px 0;
  cursor: pointer;
  border-radius: 6px;
  transition: background 0.1s;
  gap: 8px;
}

.gene-row:hover { background: var(--bg); margin: 0 -4px; padding: 6px 4px; }

.gene-rank {
  font-size: 10px;
  color: var(--text-secondary);
  width: 16px;
  text-align: right;
  flex-shrink: 0;
}

.gene-name {
  font-size: 13px;
  font-weight: 600;
  color: var(--text);
  flex-shrink: 0;
  min-width: 60px;
}

.gene-bar-wrap {
  flex: 1;
  height: 6px;
  background: var(--bg);
  border-radius: 3px;
  overflow: hidden;
}

.gene-bar {
  height: 100%;
  background: linear-gradient(90deg, var(--brand), var(--accent));
  border-radius: 3px;
  transition: width 0.4s ease;
}

.gene-vus-count {
  font-size: 11px;
  color: var(--text-secondary);
  font-weight: 500;
  flex-shrink: 0;
  min-width: 32px;
  text-align: right;
}

/* Gene detail mode */
.gene-detail { padding: 0 16px 16px; flex: 1; overflow-y: auto; min-height: 0; }

.back-btn {
  display: inline-flex;
  align-items: center;
  gap: 4px;
  font-size: 12px;
  color: var(--text-secondary);
  cursor: pointer;
  padding: 8px 0;
  background: none;
  border: none;
  font-family: var(--font);
  font-weight: 500;
  transition: color 0.15s;
}

.back-btn:hover { color: var(--brand); }

.gene-header {
  margin-bottom: 12px;
}

.gene-title {
  font-size: 22px;
  font-weight: 800;
  color: var(--text);
  letter-spacing: -0.5px;
}

.gene-meta {
  display: flex;
  gap: 8px;
  margin-top: 4px;
  flex-wrap: wrap;
}

.meta-link {
  font-size: 11px;
  color: var(--accent);
  text-decoration: none;
  font-weight: 500;
}

.meta-link:hover { text-decoration: underline; }

/* Classification counts row */
.class-counts {
  display: flex;
  gap: 6px;
  margin: 8px 0;
  flex-wrap: wrap;
}

.class-badge {
  display: inline-flex;
  align-items: center;
  gap: 3px;
  padding: 2px 8px;
  border-radius: 6px;
  font-size: 11px;
  font-weight: 600;
}

.class-badge.path { background: #FEE2E2; color: #991B1B; }
.class-badge.lp { background: #FFEDD5; color: #9A3412; }
.class-badge.vus { background: #FEF9C3; color: #854D0E; }
.class-badge.lb { background: #DCFCE7; color: #166534; }
.class-badge.ben { background: #DBEAFE; color: #1E40AF; }

/* Donut chart */
.donut-row {
  display: flex;
  align-items: center;
  gap: 12px;
  margin: 8px 0 12px;
}

.donut-svg { flex-shrink: 0; }

.donut-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 4px 10px;
  font-size: 10px;
  color: var(--text-secondary);
}

.legend-dot {
  display: inline-block;
  width: 8px;
  height: 8px;
  border-radius: 50%;
  margin-right: 3px;
  vertical-align: middle;
}

/* Classification distribution bar */
.class-dist-bar {
  display: flex;
  height: 8px;
  border-radius: 4px;
  overflow: hidden;
  margin: 4px 0 12px;
}

.class-dist-bar > div { transition: width 0.4s ease; min-width: 1px; }

/* Condition tags */
.condition-tags {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
  margin: 6px 0 12px;
}

.condition-tag {
  font-size: 10px;
  padding: 2px 8px;
  background: var(--bg);
  border: 1px solid var(--border);
  border-radius: 6px;
  color: var(--text-secondary);
  max-width: 200px;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

/* Filter chips */
.filter-chips {
  display: flex;
  gap: 4px;
  margin: 8px 0;
  flex-wrap: wrap;
}

.filter-chip {
  padding: 3px 10px;
  border-radius: 8px;
  font-size: 11px;
  font-weight: 600;
  cursor: pointer;
  border: 1.5px solid transparent;
  transition: all 0.15s;
  user-select: none;
}

.filter-chip.path { background: #FEE2E2; color: #991B1B; border-color: #FEE2E2; }
.filter-chip.lp { background: #FFEDD5; color: #9A3412; border-color: #FFEDD5; }
.filter-chip.vus { background: #FEF9C3; color: #854D0E; border-color: #FEF9C3; }
.filter-chip.lb { background: #DCFCE7; color: #166534; border-color: #DCFCE7; }
.filter-chip.ben { background: #DBEAFE; color: #1E40AF; border-color: #DBEAFE; }

.filter-chip.inactive { opacity: 0.35; }

/* Collapsible sections */
.section {
  border-top: 1px solid var(--border);
  padding: 10px 0;
}

.section-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  cursor: pointer;
  user-select: none;
  padding: 2px 0;
}

.section-title {
  font-size: 12px;
  font-weight: 700;
  color: var(--text);
  text-transform: uppercase;
  letter-spacing: 0.3px;
}

.section-toggle {
  font-size: 14px;
  color: var(--text-secondary);
  transition: transform 0.2s;
  line-height: 1;
}

.section.collapsed .section-toggle { transform: rotate(-90deg); }
.section.collapsed .section-body { display: none; }

.section-body { margin-top: 8px; }

/* Variant list */
.variant-card {
  padding: 8px 10px;
  border: 1px solid var(--border);
  border-radius: 10px;
  margin-bottom: 6px;
  cursor: pointer;
  transition: border-color 0.15s, box-shadow 0.15s;
  font-size: 12px;
}

.variant-card:hover { border-color: var(--brand); box-shadow: 0 2px 8px rgba(139,92,246,0.08); }

.variant-top {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 6px;
}

.variant-hgvs {
  font-weight: 600;
  color: var(--text);
  font-size: 11px;
  word-break: break-all;
  flex: 1;
}

.variant-class-tag {
  font-size: 10px;
  font-weight: 600;
  padding: 1px 6px;
  border-radius: 4px;
  flex-shrink: 0;
}

.variant-class-tag.pathogenic { background: #FEE2E2; color: #991B1B; }
.variant-class-tag.likely_pathogenic { background: #FFEDD5; color: #9A3412; }
.variant-class-tag.uncertain_significance { background: #FEF9C3; color: #854D0E; }
.variant-class-tag.likely_benign { background: #DCFCE7; color: #166534; }
.variant-class-tag.benign { background: #DBEAFE; color: #1E40AF; }

.variant-expanded {
  margin-top: 6px;
  padding-top: 6px;
  border-top: 1px solid var(--border);
  display: none;
  font-size: 11px;
  color: var(--text-secondary);
}

.variant-card.open .variant-expanded { display: block; }

.variant-expanded a {
  color: var(--accent);
  text-decoration: none;
  font-weight: 500;
}

.variant-expanded a:hover { text-decoration: underline; }

.variant-detail-row {
  display: flex;
  justify-content: space-between;
  margin-bottom: 3px;
}

.variant-detail-label { font-weight: 600; color: var(--text); }

.variant-pager {
  display: flex;
  justify-content: center;
  gap: 8px;
  margin-top: 8px;
}

.page-btn {
  padding: 4px 10px;
  border: 1px solid var(--border);
  border-radius: 6px;
  background: var(--surface);
  font-size: 11px;
  font-family: var(--font);
  cursor: pointer;
  color: var(--text-secondary);
  transition: all 0.15s;
}

.page-btn:hover:not(:disabled) { border-color: var(--brand); color: var(--brand); }
.page-btn:disabled { opacity: 0.4; cursor: default; }

/* Canvas charts */
.chart-canvas {
  width: 100%;
  height: 140px;
  display: block;
}

.chart-canvas.tall { height: 180px; }

/* Genome browser */
.genome-browser {
  position: relative;
  background: var(--bg);
  border-radius: 10px;
  overflow: hidden;
  border: 1px solid var(--border);
}

.genome-canvas {
  width: 100%;
  height: 120px;
  display: block;
  cursor: crosshair;
}

.genome-controls {
  display: flex;
  justify-content: center;
  gap: 4px;
  padding: 4px;
}

.genome-btn {
  padding: 2px 8px;
  border: 1px solid var(--border);
  border-radius: 6px;
  background: var(--surface);
  font-size: 11px;
  cursor: pointer;
  font-family: var(--font);
  color: var(--text-secondary);
  transition: all 0.15s;
}

.genome-btn:hover { border-color: var(--brand); color: var(--brand); }

.genome-tooltip {
  position: absolute;
  background: var(--text);
  color: #fff;
  font-size: 10px;
  padding: 4px 8px;
  border-radius: 6px;
  pointer-events: none;
  display: none;
  z-index: 10;
  max-width: 200px;
  word-break: break-all;
}

/* Concordance table */
.conc-table {
  width: 100%;
  font-size: 11px;
  border-collapse: collapse;
}

.conc-table th {
  text-align: left;
  font-weight: 600;
  padding: 4px 6px;
  border-bottom: 1.5px solid var(--border);
  color: var(--text-secondary);
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.3px;
}

.conc-table td {
  padding: 4px 6px;
  border-bottom: 1px solid var(--border);
  color: var(--text);
}

.conc-table tr:last-child td { border-bottom: none; }

.conc-discordant { color: var(--path); font-weight: 600; }
.conc-concordant { color: var(--ben); }

.conc-hgvs {
  max-width: 140px;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

/* Export bar */
.export-bar {
  display: flex;
  gap: 6px;
  padding: 10px 16px;
  border-top: 1px solid var(--border);
  justify-content: flex-end;
}

.export-btn {
  padding: 4px 12px;
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface);
  font-size: 11px;
  font-family: var(--font);
  font-weight: 500;
  cursor: pointer;
  color: var(--text-secondary);
  transition: all 0.15s;
}

.export-btn:hover { border-color: var(--brand); color: var(--brand); }

/* Loading */
.loading-spinner {
  display: flex;
  justify-content: center;
  padding: 20px;
}

.spinner {
  width: 24px;
  height: 24px;
  border: 2.5px solid var(--border);
  border-top-color: var(--brand);
  border-radius: 50%;
  animation: spin 0.7s linear infinite;
}

@keyframes spin { to { transform: rotate(360deg); } }

/* Animated number */
@keyframes countUp {
  from { opacity: 0; transform: translateY(8px); }
  to { opacity: 1; transform: translateY(0); }
}

.animate-in {
  animation: countUp 0.4s ease forwards;
}

/* Scroll area for gene detail */
.detail-scroll {
  flex: 1;
  overflow-y: auto;
  min-height: 0;
  scrollbar-width: thin;
  scrollbar-color: var(--border) transparent;
}

.detail-scroll::-webkit-scrollbar { width: 4px; }
.detail-scroll::-webkit-scrollbar-track { background: transparent; }
.detail-scroll::-webkit-scrollbar-thumb { background: var(--border); border-radius: 2px; }

/* Empty/error states */
.empty-state {
  text-align: center;
  padding: 16px;
  color: var(--text-secondary);
  font-size: 12px;
}

.error-state {
  text-align: center;
  padding: 16px;
  color: var(--path);
  font-size: 12px;
}

/* Footer */
.widget-footer {
  padding: 8px 16px;
  border-top: 1px solid var(--border);
  font-size: 10px;
  color: var(--text-secondary);
  text-align: center;
  flex-shrink: 0;
}

/* Phenotype links */
.pheno-links { display: flex; flex-wrap: wrap; gap: 4px; }
.pheno-link { font-size: 10px; color: var(--brand); text-decoration: none; background: var(--brand-light); padding: 1px 6px; border-radius: 6px; }
.pheno-link:hover { background: var(--brand); color: #fff; }

/* Search mode toggle */
.search-mode-toggle { display: flex; gap: 4px; margin-top: 2px; margin-bottom: 6px; justify-content: center; padding: 0 16px; }
.search-mode-btn { font-size: 10px; padding: 2px 10px; border: 1px solid var(--border); border-radius: 12px; background: var(--surface); color: var(--text-secondary); cursor: pointer; transition: all 0.15s; }
.search-mode-btn.active { background: var(--brand-light); color: var(--brand); border-color: var(--brand); font-weight: 600; }
.search-mode-btn:hover:not(.active) { border-color: var(--text-secondary); }

/* HPO tags */
.hpo-tags { display: flex; flex-wrap: wrap; gap: 4px; margin: 6px 0; }
.hpo-tag { font-size: 10px; background: var(--brand-light); color: var(--brand); padding: 2px 8px; border-radius: 10px; display: flex; align-items: center; gap: 4px; }
.hpo-tag-remove { cursor: pointer; font-weight: 700; opacity: 0.6; }
.hpo-tag-remove:hover { opacity: 1; }
.pheno-gene-list { margin-top: 6px; }
.pheno-diseases { display: flex; gap: 3px; flex-wrap: wrap; }

/* Computing animation */
.gene-header-loading { text-align: center; padding: 24px 16px; }
.gene-name-big { font-size: 24px; font-weight: 700; color: var(--text); margin-bottom: 12px; }
.computing-placeholder { padding: 12px 0; text-align: center; }
.computing-bar { width: 100%; height: 3px; background: var(--border); border-radius: 2px; overflow: hidden; margin-bottom: 8px; }
.computing-fill { width: 30%; height: 100%; background: linear-gradient(90deg, var(--brand), var(--accent)); border-radius: 2px; animation: computeSlide 1.5s ease-in-out infinite; }
@keyframes computeSlide { 0% { transform: translateX(-100%); width: 30%; } 50% { width: 60%; } 100% { transform: translateX(350%); width: 30%; } }
.computing-text { font-size: 11px; color: var(--text-secondary); animation: pulse 2s ease-in-out infinite; }
@keyframes pulse { 0%,100% { opacity: 0.5; } 50% { opacity: 1; } }

/* Alert button + form */
.alert-btn { font-size: 10px; padding: 2px 8px; border: 1px solid var(--brand); border-radius: 6px; background: var(--brand-light); color: var(--brand); cursor: pointer; font-weight: 600; }
.alert-btn:hover { background: var(--brand); color: #fff; }
.alert-form { margin-top: 8px; padding: 8px; background: var(--brand-light); border-radius: 8px; }
.alert-email-input { width: 100%; font-size: 11px; padding: 5px 8px; border: 1px solid var(--border); border-radius: 6px; margin-bottom: 4px; font-family: var(--font); }
.alert-submit-btn { font-size: 10px; padding: 3px 12px; border: none; border-radius: 6px; background: var(--brand); color: #fff; cursor: pointer; font-weight: 600; }
.alert-submit-btn:hover { background: var(--brand-hover); }

.widget-footer a { color: var(--brand); text-decoration: none; }
.widget-footer a:hover { text-decoration: underline; }